Regular Article PLATELETS AND THROMBOPOIESIS Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function
نویسندگان
چکیده
Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Department of Cell Biology, Erasmus MC, Rotterdam, The Netherlands; Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Center for Biomics, and Proteomics Center, Erasmus MC, Rotterdam, The Netherlands; and Institute of Molecular Biology and Tumor Research, Philipps-University Marburg, Marburg, Germany
منابع مشابه
Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoeitin/MGDF in megakaryocyte development
Despite the importance of blood platelets in health and disease, the mechanisms regulating their formation within megakaryocytes are unknown. We generated mice lacking the hematopoietic subunit (p45) of the heterodimeric erythroid transcription factor NF-E2. Unexpectedly, NF-E2-/- mice lack circulating platelets and die of hemorrhage; their megakaryocytes show no cytoplasmic platelet formation....
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تاریخ انتشار 2015